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Dong Gwan Han  (Han DG) 72 Articles
Original Article
Ultrasonographic Bladder Parameters for Successful Suprapubic Bladder Aspiration
Sung Chul Baek, Hoe Kyoung Koo, Cheol Hong Kim, Kyung Bum Kim, Hyun Hee Lee, Byung Min Choi, Kee Hwan Yoo, Young Suk Hong, Dong Gwan Han
Clin Exp Pediatr. 2004;47(2):187-192.   Published online February 15, 2004
Purpose : Suprapubic bladder aspiration(SBA) is a widely accepted method of obtaining sterile urine for culture in neonates but has a relatively low success rate and a few serious complications during SBA procedure. To improve the chance of obtaining urine, we determined the ultrasonographic bladder parameters(diameters and volume) to confirm that the bladder is adequately distended for successful aspiration of...
Physical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant
Chul Lee, Min Soo Park, Moon Sung Park, Jung Nyeon Kim, Jong Wook Lee, Kwang Hyun You, Won Jae Kwag, Kook In Park, Ran Nam gung, Dong Gwan Han
Clin Exp Pediatr. 1997;40(6):771-785.   Published online June 15, 1997
Purpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in premature babies. For the treatment of RDS at present surfactants such as Surfacten․ (Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant from the Ministry of Science and Technology for a model research project of Medium-Technology program, we have modified (supplemented) the bovine lung...
Risk factors for Pulmonary Interstitial Emphysema(PIE) in Mechanically Ventilated Neonates with Hyaline Membrane Diseas
Shin Won Yoon, Chul Lee, Jeong Nyun Kim, Ran Namgung, Dong Gwan Han, Myung Joon Kim
Clin Exp Pediatr. 1997;40(3):318-326.   Published online March 15, 1997
Purpose : Pulmonary interstitial emphysema(PIE) is a common and serious complication of mechanical ventilation in infants with hyaline membrane disease. This abnormal collection of gases has two basic roentgenographic features; linear and cyst-like radiolucencies. High positive inspiratory pressure was found to be the most significant parameter associated with development of fatal pulmonary interstitial emphysema. Without prompt conservative management such as lowering peak inspiratory...
Case Report
A Case of Antley-Bixler Syndrome
Young Rae Kim, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1995;38(4):582-585.   Published online April 15, 1995
Antley-Bixler syndrome is a very rare disese of characteristic feature of craniosynostosis, brachycephaly, midface hypoplasia, depressed nasal bridge, radiohumeral synostosis and bowing femur. We presented a case of Antley-Bixtler syndrome with brief review of lituratures.
Original Article
Assessment of Infantile Mental and Motor Development Influenced by Breast Milk and Formula Feeding
Chul Lee, Min Soo Park, Young Mi Chung, Hye Jung Joo, Kwang-Moon Kim, Dong Gwan Han
Clin Exp Pediatr. 1995;38(3):289-296.   Published online March 15, 1995
Purpose : This study was undertaken to compare the mental and motor development, unsing Bayley Developmental Scale, during infancy(6-8 months of age) according to the choice of feeding, either breast milk of formula, as well as to evaluate its influence on physical growth. Methods : The study population was 43 normal infants between 6 and 8 months of age, of birth...
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Case Report
A Case of Phakomatosis Pigmentovascularis
Seung Mo Park, Kook In Park, Hye Jung Joo, Ran Namgung, Chul Lee, Dong Gwan Han, Soo Il Chun
Clin Exp Pediatr. 1994;37(8):1156-1161.   Published online August 15, 1994
In 1947, Ota et al. First reported a case of phakomatosis pigmentovascularis and defined a subgroup of this disease having a congenital generalized hemangioma and pigmented lesions including anmongolian spot-like lesion, nevus pigmentosus and nevus of Ota. We experienced a case of phakomatosis pigmentovascularis type Iib in a 10-day old male baby, who since birth, had generalized nevus flammeus and...
Original Article
Intraventricular Hemorrhage in Full-Term Neonate
Myoung Bae Jeon, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(6):776-785.   Published online June 15, 1994
Intraventricular hemorrhage is a common hemorrhagic cerebral disorder in premature, but occurs much less frequently in the full-term newborn. In order to obtain documentation of clinical and ultrasonographic characteristics of intraventricular hemorrhage in full-term, we performed cerebral ultrasonography on 602 newborn infants who had been admitted to neonatal intensive care unit at the Deppartment of Pediatrics, Yonsei University College of...
Case Report
A Case of Brain Damage in Surviving Monozygotic Twin After Intrauterine Death of Co-Twin
Jae Young Choi, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Tae Sub Chung
Clin Exp Pediatr. 1994;37(5):701-706.   Published online May 15, 1994
Various anatomical defects have been described in the surviving twin who had a stillborn, macerated monozygotic co-twin Disseminated Intravascular Coargulation. The etiology is thought to be placental transfer of emboli or thromboplastic material through placental vascular anastomoses. We experienced a case of monozygotic twin with deceased co-twin at 30 weeks of gestation and confirmed to have antenatal periventricular germinal matrix and...
Original Article
Tc-99m HMPAO Brain SPECT in a Patient with Neonatal Seizure and Right Cerebral Hemiatrophy
Hye Young Kang, Kook In Park, Ran Namgung, Chul Lee, Chang Jun Coe, Dong Gwan Han, Tae Sub Chung, Woo Hee Jung
Clin Exp Pediatr. 1994;37(3):397-404.   Published online March 15, 1994
Functional brain imaging is very important in the diagnosis and evaluation of the various neurologic disorders. In addition to electroencephalography (EEG) and positron emission tomography (PET), single photon emission computed tomography (SPECT) have increasingly gained importance in determination of disturbances in regional brain functions. Both ictal and interictal Tc-99m hexamethyl-propyleneamine oxime single photon emission computed tomography (Tc-99m HMPAO SPECT) was done...
Evaluation of Development of Normal Infants Using Bayley Developmental Test
Young Mi Chung, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1994;37(11):1508-1518.   Published online November 15, 1994
From April to September 1992, 40 infants with age 6 months to 8 months who had been born in Yongdong Severanve Hospital were studied for evaluation of their development using Bayley developmental test. The result obtained were as follow: 1) Mean mental developmental index(MDI) is higher than mean psychomotor developmental index (PDI) and the values are 101.9¡¾8.2 and 105.5¡¾9.8 respectively. 2) As...
Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(10):1357-1363.   Published online October 15, 1994
In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University...
Clinical and Ultrasonographic Study on Prenatal Brain Damage in Newborn Infants
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(10):1364-1375.   Published online October 15, 1994
To determine the incidence of prenatal brain damage, and evaluate the clinical and neurosonographical characteristics, we prospectively examined 508 newborn infants with intracranial ultrasound within the first day of life who admitted to the NICU of Severance Hospital from June 1990 to January 1992 and reviewed maternal or neonatal medical records. We found 12 cases(2.4%) of fetal brain...
Case Report
A Case of Cerebrocostomandibular Syndrome with Congenital Heart Disease
Sang Heui Song, Kook In Park, Hye Jung Joo, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1993;36(4):574-578.   Published online April 15, 1993
Cerebrocostomandibular Syndrome is characterized by micrognathia, cleft palate, multiple thorax deformity and frequently, mental deficiency. Respiratory compromise is a common cause of death. We experienced a case of cerebrocostomandibular syndrome with congeniyal heart disease in a 2 day old female baby with the chief complaint of cyanosis and respiratory difficulty since birth, She was delivered by cesarian section due to delayed...
Erratum
Measurement of Bone Mineral Density in Korean Newborns by Dual Photon Absorptiometry
Kook In Park, Chul Lee, Ran Namgung, Duk Hi Kim, Dong Gwan Han
Accepted January 1, 1970  
Bone mineral density (BMD), bone mineral content (BMC) and bone width (BW) of lumbar spine was measured in 37 term and 38 preterm appropriate-for-gestational-age (AGA) infants and 22 term small-for-gestational-age (SGA) infants who were delivered at Yonsei University Severance Hospital from January to September 1991 using dual photon absorptiometry (DPA). All of the infants were studied once within three days...
Original Article
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with the Doppler Technique
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee, Jin Suk Suh, Myung Joon Kim
Clin Exp Pediatr. 1992;35(1):60-68.   Published online January 15, 1992
Eighty-one asymptomatic preterm, term-SGA, and full term infants who were delivered at Yonsei University Severance Hospital from January to July 1990 were studied with color duplex imaging doppler sonography to assess the postnatal changes of the cerebral blood flow velocity longitudinally. Pulsatility index (PI) and area under the velocity curve (AUVC) were calculated to quantitate changes in anterior cerbral artery blood...
A case of neonatal herpes simplex virus encephalitis.
Kook In Park, Young Mo Sohn, Dong Soo Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Won Young Lee, Ki Keun Oh, Myung Joon Kim
Clin Exp Pediatr. 1991;34(9):1276-1285.   Published online September 30, 1991
Neonatal herpes simplex virus infection still remains a life-threatening infection for the newborn. With an increasing incidence of genital herpes and an increase in the incidence of neonatal herpes simplex virus infections, it is important that pediatricians and neonatologists continue to maintain a high index of suspicion in infants whose symptoms may be compatible with herpes simplex virus infections so that early identification leads...
Predictive factors and initial selection of antibiotics in neonatal sepsis.
Dong Chul Park, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(6):755-762.   Published online June 30, 1991
For simplifying and standardizing the interpretation of usual findings for neonatal sepsis, prenatal and perinatal factors, clinical symptoms and signs, method of management and hematologic findings were evaluated as a screening test. From the data obtained, a scoring system was formulated that assigns a score of 3 for diarrhea, 1. 5 for tachypnea, 1.5 for cyanosis, 1 for umbilical vessel catheterization, 1 for intravenous...
Effect of fluid restriction on postnatal weight and outcome in very low birth weight infants.
Chul Lee, Hyeon Soo Lee, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(3):348-354.   Published online March 31, 1991
We studied 45 very low birth weight infants for change in birth weight, urine output, serum Na level, ventilatory support and outcome between two groups after fluid restriction therapy. Group 1 (n=17) were infants whose weight loss were more than 5% of birth weight. Group 2 (n=17) were infants whose weight loss were more than 5% of birth weight. 1) Group 1 had more fluid...
Transplacental transmission of hepatitis B virus from carrier nothers to neonates.
Soh Yeon Kim, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(2):190-196.   Published online February 28, 1991
Neonates bom to hepatitis B carrier mothers at Yongdong Severance Hospital, Yonsei University College of Medicine were sampled for hepatitis B viral markers using venous blood drawn from external jugular vein within 3 hours after birth and the following results were obtained. Two thousand nine hundred and seventy two pregnant women who received prenatal care at Yongdong Severance Hospital, Yonsei University College of Medicine...
A case of type VI Ehlers-Danlos syndrome.
Ki Soo Pai, Young Mi Chung, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(12):1717-1723.   Published online December 31, 1991
Ehlers-Danlos syndrome is an inherited hetergenous disorder of connective tissue with characteris- tic clinical manifestations. In this article, a case of Ehlers-Danlos syndrome is presented. A nine months old female was admitted due to developmental delay. On physical examination, she had soft velvety skin and corneal opacity. Both hip joints were positive for Barlow test. There was hyper- mobility of both knee and elbow...
The role of exchange transfusion as a therapy for neonatal DIC.
Jung Tak Kim, Kook In Park, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1991;34(1):31-40.   Published online January 31, 1991
A clinical study on the effects of exchange transfusion on disseminated intravascular coagulation was conducted on 32 patients with DIC who were admitted to the pediatric department of YUMC from January 1984 to June 1989. We diagnosed DIC when symptoms were compatible to the diagnosis and there were more than 3 abnormal laboratory findings out of the following 5, which were platelet count, PT,...
Dubowitz Neurologic Examination in Normal Neonates.
Young Soo Lee, Soh Yeon Kim, Dong Chul Park, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1990;33(7):977-988.   Published online July 31, 1990
With the improvement in survival rate in high risk infants in the neonatal intensive care unit, there is rising concern about the neurologic sequelae in these infants. In order to evaluate the neur- ologic examination in normal neonates, 400 normal newborns were evaluated for a duration of 6 months from Mach 1989 to August 1989. Neonates greater than 37 weeks gestational age, birth weight...
Prolapse of Ileal Mucosa Through the Patent Omphalomesenteric Duct.
Hwan Gyu Park, Ki Soo Pai, Jeong Wan Yoo, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Eui Ho Hwang, In Joon Choi
Clin Exp Pediatr. 1990;33(12):1713-1717.   Published online December 31, 1990
The omphalomesenteric duct in the embryo is a communication between the yolk sac and primitive gut. The duct closes by six to eight weeks of intrauterine life and disappears soon after. Patent omphalomesenteric duct is a congenital anomaly which occurs when there is incomplete closure of the duct during this period. The authors experienced a cases whereby a 29-day old male baby had patent...
Clinical Study of Umbilical Vessel Catheterization in Newborn Infants.
Dae Shik Kim, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1990;33(11):1503-1509.   Published online November 30, 1990
Umbilical vessel catheterization has become a common procedure in critically ill newborn infants. We studied the usefulness and complications of indwelling umbilical vessel catheters in 164 patients who were admitted to the neonatal intensive care unit of the Department of Pediatrics, Yonsei University Hospital from January 1985 to December 1988. The results were as follows: 1) Their birth weights ranged from 650 to 3,800 gm, and...
The Effect of Phototherapy on Serum bilirubin Binding Capacity and Affinity in the Neonate.
In Suck Ryu, Chul Lee, Ran Namkung, Dong Gwan Han
Clin Exp Pediatr. 1990;33(10):1319-1325.   Published online October 31, 1990
Since the effect of phototherapy in the treatment of neonatal hyperbilirubinemia has been reported 30 years ago, phototherapy has been used widely for neonatal hyperbilirubinemia, but the exact mechanism and the effect of light on the human body have not been fully determined. Free bilirubin level in the serum is an important indicator for kemicterus, a complication of neonatal hyperbilirubinemia. Free bilirubin level was...
Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran Namgung, Chul Lee, Kook In Park, Dong Gwan Han
Clin Exp Pediatr. 1990;33(1):22-34.   Published online January 31, 1990
We conducted a clinical controlled trial of exogenous surfactant replacement therapy in premature infants with hyaline membrane disease at the neonatal intensive care unit of Yonsei University Medical Center form Nov. 1987 to May 1988. Sixteen premature infants with severe HMD were randomly assigned to control group or surfactant-treated group. Eight infants (mean gestational age 29.9±2.8 week, mean birth weight 1, 425±308.9 gm) were given...
A Study on Noninvasive Measurement of Blood Pressure in Normal Newborn.
Eun Hee Lee, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1989;32(9):1216-1223.   Published online September 30, 1989
Measurement of blood pressure in neonate is an important diagnostic procedure. But measurement of blood pressure were not performed routinely because of difficulty in measuring blood pressure and variable normal range according to measuring apparatus. Recently some accurate and convinient apparatuses of measuring blood pressure have been introduced in neonatal care, so normal blood pressure values of neonate are needed. In this study, we establish...
Ultrasonographic Diagnosis of Congenital Hypertrophic Pyloric Stenosis.
Shin Heh Kang, Chul Lee, Ran Namgung, Dong Gwan Han, Ki Keun Oh, Seung Hun Choi
Clin Exp Pediatr. 1989;32(6):756-764.   Published online June 30, 1989
The diagnosis of congenital hypertrophic pyloric stenosis has traditionally been made on the basis of history and physical examination in the majority of patients. Imaging procedures such as UGI series have been reserved for vomiting infats in whom the diagnosis was obscure. More recently ultrasonography with the lack of hazards associated with radiation provides an additional method of investigation which is accurate and diagnose...
Two Cases of Poland Syndrome.
Kul Ha Yoo, Ki Soo Pai, Byung Ju Chung, Chul Lee, Dong Gwan Han, Jong Doo Lee
Clin Exp Pediatr. 1989;32(5):713-717.   Published online May 31, 1989
Poland syndrome is characterized by an absence of the pectoralis major muscle, with ipsilateral defect of the upper extremity, usually syndactyly. The incidence of this syndrome has been estimated at 1 per 25,000 to 77,000 persons and more than 100 patients have been described worldwide. Recently, we experienced two patients, the one was 14 year old male, who showed absence of left pectralis maior...
Postnatal Weight Curve in Low Birth Weight(Appropriate for Gestational Age) Infants.
Kyoung Mi Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1989;32(5):606-619.   Published online May 31, 1989
Postnatal body weight changes were observed in 171 surviving infants with birth weights from 875 gm to 2,125 gm who were born at Severance Hospital, Yonsei University College of Medicine form 1981 to 1987. Only infants whose sizes were appropriate for gestational age were included in the study. Infants were divided into 5 groups by biπh weight, with the median weight were 2,000 gm,...
A case of congenital posterior choanal atresia.
Dae Shik Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Seung Kyu Chung
Clin Exp Pediatr. 1989;32(11):1546-1552.   Published online November 30, 1989
The congenital posterior choanal atresia is an uncommon, but not rare, disorder that may threaten the newborn’s existence or give rise to chronic symptoms. As many as 50% of patients with choanal atresia have other associated anomalies. We experienced a case of congenital posterior choanal atresia without associated anomaly in 6 day old female baby. The patient was hospitalized due to the main symptoms...
7 Cases of Group B Streptococcal Meningitis and Sepsis.
Young Wan Kim, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(7):873-880.   Published online July 31, 1988
We report 7 cases of Group B streptococcal meningitis and sepsis. Six of the patients were admitted to the Department of Pediatrics, Severance Hospital and Youngdong Severance Hospital in 1986 and one was admitted in 1979. The age of onset ranged from 10 to 34 days of age and all were cases of late onset. The Clinical findings were fever, seizure, poor feeding,...
A Study on the Blood Pressure Measurements in Newborn.
Ran Namgung, Ki Soo Pai, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(5):541-546.   Published online May 31, 1988
Non invasive blood pressures measured by the Dinamap monitor, an oscillometric device, were compared with the invasive radial artery pressure in neonates. There were 21 patients with a mean age of 16.5 days (ranges 7 days to 1 month) and a mean body weight of 3.3 kg. The invasive radial artery pressures were recorded on a strip chart and comparisons were made between the...
A Case of Persistent Fetal Circulation.
Jong Kyun Lee, Chul Lee, Ran Namgung, Sung Kyu Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(2):234-240.   Published online February 28, 1988
The authors have experienced a case of persistent fetal circulation associated with hypocalcemia. The baby was delivered with full-term by repeated cesarean section. He showed marked dyspnea 4 hours after birth and thereafter cyanosis appeared. So artificial ventilator had been applied combined with tolazoline administration. The patient was treated successfully and discharged on 28th hospital day without complications. We present one case of persistent fetal...
The Direct Coombs Test and Heat Elution Test in ABO Incompatible Hemolytic Disease of the Newborn.
Kook In PArk, Chul Lee, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1988;31(12):1633-1640.   Published online December 31, 1988
The clinical study on 28 cases of ABO HDN who were diagnosed at Pediatric Department of Severance hospital and Yong Dong Severance hospital, Yonsei University for last 5 months was. And in these cases, heat elution test in combined with direct Coombs test using standard techniques were performed to evaluate the clinical significance of serological diagnosis. The following results were obtained. 1) Of 28 ABO HDN...
Neurosonographic Follow-up Study in Low Weight Infants.
Yil Sub Lee, Chul Lee, Ran Namgung, Dong Gwan Han, Ki Keun Oh
Clin Exp Pediatr. 1988;31(12):1573-1579.   Published online December 31, 1988
Serial neurosonographic examinations were performed in 34 low birth weight infants who were admitted to the neonatal intensive care unit of Yong-Dong Severance Hospital. Among them, 14 (41 %)were found to have periventicular-intraventricular hemorrhage. The initial hemorrhage occured in the first three days of life among 71% infants. After initial hemorrhage, hemorrhage was decreased in size and thereafter absorbed. Fourteen (44%) infants demonsrated cysts...
A Study of Transcutaneous Oxygen Monitoring in Neonatal Intensive Care.
In Suck Ryu, Chul Lee, Ran Namkung, Dong Gwan Han
Clin Exp Pediatr. 1988;31(11):1417-1424.   Published online November 30, 1988
191 simultaneous measurement of arterial PO2 and transcutaneous PO2 were made in 14 sick infants from November, 1986 to April, 1987 who were admitted to the Neonatal Intensive Care Unit of Yongdong Severance hospital. Differences between TcPO2 and PaO2 in these sick infants were evaluated in the relation to systolic blood pressure, hematocrit, arterial pH and birth weight. There was a linear relationship and...
Bilirubin-Binding Capacity of Albumin in Korean Neonates.
Jung Bae Lee, Chul Lee, Ran Namgung, Dong Gwan Han, Kyung Son Song
Clin Exp Pediatr. 1988;31(10):1259-1266.   Published online October 31, 1988
The binding of bilirubin by albumin is thought to play an important role in the pathogenesis of kemictems. Free bilirubin hypothesis has led to develop methods to evaluate the binding capacity and affinity of bilirubin to albumin in the plasma. Horseradish peroxidase oxidation of free bilirubin can estimate the level of free bilirubin, bilirubin binding capacity and bilirubin binding affinity. Twenty four term infants...
The Result of Intensive Care on the very Low Birth Weight Infants(1001~1500gm).
Seo Jeong Kim, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1988;31(1):29-39.   Published online January 31, 1988
The clinical study on the results of intensive care was performed on the 137 very low birth weight infants with birth weight of 1001-1500 gram who were admitted to the neonatal intensive care unit of Severance hospital from 1981 to 1986. The results were as follows. 1) The range of gestational age of very low birth weight infants was from 22 to 40 weeks, most predominantly...
Case Report
Neonatal Tetanus Treated with Intermittent Positive-Pressure Ventilation.
Ran Namgung, Chuhl Joo Lyu, Chul Lee, Youn Ha Kang, Dong Gwan Han
Clin Exp Pediatr. 1987;30(6):671-676.   Published online June 30, 1987
We report our experience with Neonatal Tetanus treated with Intermittent Positive-Pressure Ventilation combined with Neuromuscular blockade and high dose diazepam. Duration of mechanical ventilation was ranged from 15 days in case 1 to 36 days in case 2. Pneumonia with atelectasis and sepsis due to pseudomonas cepacia was complicated in case 2, but cleared up with sensitive antibiotics and vigorous physiotherapy. Muscle relaxation and sedation...
Original Article
Clinical observation in the Clavicle Fracture in Newborn.
Kee Hyuck Kim, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1986;29(12):1319-1323.   Published online December 31, 1986
The following is the result of a retrospective clinical study on the clavicle fractures iit 33 newborns who were delivered at Yonsei University Medical Center during the eight years between 1978 and 1985. 1) The incidence of clavicle fractures was 2 per 1,000 deliveries and there was no difference in incidence by sex. 2) The incidence of clavicle fracture by the birth weight was...
Clinical observation in 72 Cases with Neonatal Sepsis.
Jae Seung Yang, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1986;29(12):1309-1313.   Published online December 31, 1986
Since the clinical features of neonatal sepsis were first reported by Dunham in 1933, there have been many studies. But because of the uncertain early symptoms and it’s rapid progression, the mortality rate of neonatal sepsis runs still high. We are reporting 72 cases of neonatal sepsis confirmed by clinical symptoms and blood culture studies over 3 years and 5 months between...
Clinical Studies on Enteropathogenic E.Coli Enteritis in a Newborn Nursery.
Chang Hyun Yang, Ran Nam Gung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1986;29(11):1187-1195.   Published online November 30, 1986
We experienced 20 cases of infantile diarrhea caused by Enteropathogenic E. Coli during 2 months from May. 1985 to Jun. 1985 at Yonsei medical center, Newborn nursery. The onset of illness is ususally slow vague signs of reluctance to feed lethargy, spitting up of formula, mild abdominal distention and diarrhea. The outbreak abated abruptly after institution of strict aseptic technique,...
Incidence and Risk Factors of Periventricular and Intraventricular Hemorrhage in Low Birth Weight Infants.
Chul Lee, Heung Dong Kim, Ki Keun Oh, Dong Gwan Han
Clin Exp Pediatr. 1986;29(11):1179-1186.   Published online November 30, 1986
Real time ultrasound scans were performed on 54 low-birth weight infants within the 7th 'birth day. Fifty infants were inborn. The incidence of periventricular and intraventricular hemorrhage (PV-IVH) was 38.9%. Seven of 21 infants had mild hemorrhage (Papile, grade I and II): Others sustained severe hemorrhage(Papile, grade III and IV ). Low Apgar score, respirator care and use of dopamine...
The relationship between Dose of Hepatitis B Vaccine and Seroconversion Rate in Infants.
Jung Hye Choi, Ki Sup Chung, Dong Gwan Han
Clin Exp Pediatr. 1986;29(10):1080-1086.   Published online October 31, 1986
After the discovery of Australia antigen by Blumberg et al in 1965, subsequent studies revealed that Australia antigen is identical with surface antigen of hepatitis B virus. The infants born to HBsAg positive mother can be protected from perinatal hepatitis B virus infection with hepatitis B vaccine and hepatitis B immunoglobulin. If the dose of vaccine can be reduced from...
A Clinical Study of Wet Lung Disease.
Soon Wook Lim, Jae Seung Yang, Chul Lee, Dong Gwan Han, Chin Suck Suh
Clin Exp Pediatr. 1985;28(9):852-860.   Published online September 30, 1985
The authors studied 36 cases of wet lung disease who were born and admitted to pediatric department of Severance hospital from January 1981 to June 1984. following results were obtained: 1)The incidence of wet lung disease was 0.5% and the predisposing factors were male sex(78%), full term(75%), C-section(58%) and multipara(72%). 2)Number of cases whose Apgar score were above 7 werp...
Peumomediastinum in the Newborn.
Dong Gwan Han
Clin Exp Pediatr. 1985;28(3):217-224.   Published online March 31, 1985
A retrospective review was performed of 15 medical records to study the pneumomedia- stinum in the newborn during last 4 years from Jan. 1980 through Dec. 1983 at Severance Hospital of Yonsei University. Tne results were as follows: 1) The incidence was 0.14% (15 of 8,737 live-births) during the neonatal period. Of those cases spontaneous pneumomediastinum was 66.7%(10 cases) and secondary pneumomedia- stinum 33.3%(5 cases). Males were...
Secondary Pneumothorax in the newborn.
Dong Gwan Han
Clin Exp Pediatr. 1985;28(2):123-130.   Published online February 28, 1985
Clinical records of 25 neonates with secondary pneumothorax were reviewed retrospectively during last 6 years from Jan. 1978 through Dec. 1983 at Pediatric Department of Yonsei University Hospital. The following results were obtained; 1)The incidence of secondary pneumothorax was 0.16% (21 out of 12,864 live-birth) during the neonatal period. The incidence tended to increase since we had set up the neonatal,...
Spontaneous Pneumothorax in the Newborn.
Dong Gwan Han
Clin Exp Pediatr. 1985;28(1):16-24.   Published online January 31, 1985
A retrospective 13 medical records of symptomatic and spontaneous pneumothorax of newborn has been reviewed, which occurred during last 13 years from Jan. 1971 through Dec. 1983 at Pediatric Department of Yonsei Medical School. Spontaneous pneumothorax was defined one with pneumothorax which was not given positive pressure or intubation. And following results W6re obtained; 1)The incidence of spontaneous pneumothorax in...
A Study on Intrauterine Growth Standard.
Young Ho Kim, Dong Gwan Han
Clin Exp Pediatr. 1984;27(6):531-542.   Published online June 30, 1984
The use of some system on a nursery service which facilitates the recognition of infants born with birth weights disproportionate for their gestational age, either too large or to(x small, is becoming increasingly important in pediatrics. But, these recognition is possible only when birth weight-gestational age table is present. The purpose of this study is to establish the more accurate...
Clinical Study of the role of Exchange Transfusion for Treatment in Neonatal DIC.
Myung Shik Lee, Jin Sung Lee, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1984;27(12):1151-1161.   Published online December 31, 1984
This study was made of 9 cases of neonatal septicemia complicated with DIC and sclerema, who were admitted to the pediatric department of YUMC from January 1981 to June 1983. The following results were obtained; 1) A higher incidence was observed in males(77.8%), low birth weight(66.7%) and1 pretnature(77.8%). 2) The mean onset of sepsis was noticsd on 4.4 days of life. The most common presenting symptoms...
A Clinical Study on Morbidity and Mortality in Newborns of Mothers wieh Premature Rupture of Membrane.
Myung Shik Lee, Dong Gwan Han
Clin Exp Pediatr. 1984;27(11):1045-1054.   Published online November 30, 1984
A clinical study was made on 997 newborns of mothers with premature rupture of membrane (study group) and 5,552 newborns of mothers without ruptured membrane (control group) at YUMC from January 1981 to December 1983. The following results were obtained: 1) The incidence of the study group was 15.2% and morbidity incidences were 5.4% due to sepsis, 9.5% due to asphyxia and...
A Clinical Observation of Congenital Anomalies Born with Hydramnios.
Kook In Park, Myung Shik Lee, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1984;27(10):991-999.   Published online October 31, 1984
This is a clinical observation of congenital anomalies in 55 newborn infants associated with hydramnios. These infants were born at Severance Hospital from Sep. 1975 to Jun. 1983. The results were as follows: 1) The frequency of hydramnios was 49 cases in 160,060 deliveries in that period, which was 0.31%. 27 infants (49.1%) had congenital anomalies of 55 infants associated with hydramnios...
A Clinical Observation of Meconium Aspiration Syndrome.
Chul Lee, Kook In Park, Jean Young Lee, Dong Gwan Han
Clin Exp Pediatr. 1984;27(10):958-964.   Published online October 31, 1984
The Authors observed 51 cases of meconium aspiration syndrome in newborns who were born at Severance Hospital during the period of Jan. 1980 through Jun. 1983. The following results were obtained: 1) The incidencs of meconium aspiration syndrome was 0.6%(51 cases). 2)88.2% of newborn with meconium aspiration syndrome was weighing more than 2,500 gm and 93.1% of that was with a...
Case Report
A Case of Cryptococcal Hepatitis.
Jeong Sik Park, Jae Song Kim, Dong Gwan Han, Duk Jin Yun
Clin Exp Pediatr. 1979;22(6):465-470.   Published online June 15, 1979
A case of cryptococal hepatitis in a 4-year-old girl was presented with a brief review of the literature. She was admitted with the chief complaints of jaundice, abdominal pain, and semicomatose mental state. Treatment was started including dexamethasone under impression of fulminant hepatitis. During treatment massive G-I bleeding appeared which required eleven pints of blood and 20 days for control....
Original Article
Fetomaternal Transfusion.
Dong Gwan Han, Chul Lee, Kir Young Kim, Hyo Kyu Kim
Clin Exp Pediatr. 1979;22(4):306-312.   Published online April 15, 1979
From Feb, 1977, through Aug. 1977, 100 venous blood samples obtained from women within 48 hr after delivery were examnied for fetomaternal transfusion by the Nierhaus acid elution technique. Blood smears were scanned at 100 high power field for enumeration of fetal erythrocytes. 1. The incidence of fetomaternal transfusion was 26% 2. The incidence of fetomaternal transfusion was the highest...
Clinical and Statistical Study on the Congenital Anomalies of the Digestive system.
Chee Ok Ahn, Tai Euk Kim, Dong Gwan Han, Duk Jin Yun
Clin Exp Pediatr. 1978;21(6):440-451.   Published online June 30, 1978
A study was conducted to present clinical and statistical analysis of pediatric patients admitted to Severance Hospital between Jan. 1966 and Dec. 1975. Remakable progress has been made in the field of pediatrics and pediatric surgery, particularly in physiology, anesthesiology and operative technique. However, the ultimate result hasn't been totally satisfactory, largely due to the lack of cognizance of early...
Case Report
Five cases of Congenital Hydronephrosis in Infancy.
Chul Lee, Hong Kyu Lee, Jae Song Kim, Dong Gwan Han, Duk Jin Yun, Jin Moo Lee
Clin Exp Pediatr. 1978;21(5):396-402.   Published online May 31, 1978
This is a clinical observation of five infants associated with congenital hydronephrosis experienced at the Pediatric Department of Severance Hospital. The results were as follows: 1. The age distribution was from one day to seven months with the sex radio of 4 : 1 with male predominance. 2. The signs most freguently found were palpable abdominal mass and abdominal distension....
Original Article
Clinical Studies on Neonatal Hepatitis.
Hong Kyu Lee, Moon Hee Lee, Dong Gwan Han, Duk Jin Yun
Clin Exp Pediatr. 1978;21(5):389-395.   Published online May 31, 1978
43 cases of neonatal hepatitis were clinicallt evaluated, who were admitted to the pediatric department of Severance hospital furing period from April, 1956 to Februart, 1976. The following results were obtained. There was little difference in sex incidence, and most of them were admitted at the age of 1 month to 3 months after birth. Clinical symptoms and signs on...
Perinatal Mortality rates: IV. A Practical Classification of Infants by Birth weight and Gestational Age.
Dong Gwan Han, Hyo Kyu Kim
Clin Exp Pediatr. 1977;20(7):526-531.   Published online July 31, 1977
There were 544 perinatal deaths out of 11,336 single births who were delivered at Severance, Chonju Presbyterian and Wonju Christian Hospitals. The Perinatal mortality rates were calculated at fetal deaths of 20 or more weeks?gestation plus neonatal deaths under 28 days after birth. We made a comparative studies of classification about the perinatal and neonatal mortality reports on the literatures....
Perinata Mortality Rate: III Comparaative Studies Among 3-Hospitals.
Dong Gwan Han, Kyung Sook Park, Duk Jin Yun
Clin Exp Pediatr. 1977;20(7):516-525.   Published online July 31, 1977
For 3 yearss from Jan. 1970 through Dec. 1972, there were 11,336 Korean single births who were delivered at Severance, Chonju Presbyterian and Wonju Christian Hospitalss. The perinatal mortality rates were calculated at fetal deaths of20 or more weeks gestation plus neonatal deaths under 28days after births. We made a comparative studies of perinatal mortality, neonatal mortality and fetal deaths...
A Clinical Observation of Congenital Anomalies born with Hydramnios.
Kyong Kyun Shin, Pil Rea Chung, Soo Yung Whang, Jong Soo Kim, Dong Gwan Han
Clin Exp Pediatr. 1977;20(1):20-27.   Published online January 31, 1977
This is a clinical observation of congenital anomalies in 97newborn infants associated with hydramnios. These infants were born at severance Hospital, Wonju Christian Hospital and Jeonju Presbyterian Hospital from Jan. 1966 to Aug. 1975. The results were as follows: 1. The frequency of hydramnios was 86 cases in 25,566 deliveries in that period, which was 0.34%. 40infants (41.2%) has congenital...
Case Report
A case of primary peritonitis
Jae Song Kim, Jung Sang Oh, Seockoo Bai, Dong Gwan Han, Seung Kock Son, Eui Ho Hwang
Clin Exp Pediatr. 1976;19(6):421-424.   Published online June 30, 1976
A 2 month old male infant was admitted to Severance hospital due to bile stained vomiting; and abdominal distention for 2 days via emergency room. On physical examination, acutely ill appearance with lethargy, subnormal temperature, sunken fontanel, dry mouth, coated tongue, abdominal distention, and absent bowel sounds were noted and clinical impression could not be ruled out paralytic ileus due...
Original Article
Clinical Studies of Typhoid fever in Children
Jae Song Kim, Moon Hee Lee, Dong Gwan Han, Dong Shic Jin
Clin Exp Pediatr. 1976;19(4):263-271.   Published online April 30, 1976
During the last 8 years from Jan. 1967 to Dec. 1974, 107 cases of typhoid fever has been admitted to the department of Pediatrics, Severance hospital and evaluated clinically. This is an additional study of the previous report from 1957 to 1966. The results were summarized as follows: 1.Total number of the patients was 107 and 62 were male and...
Clinical studies on 32 subdural effusions
Kwang Yean Chung, Soo Hyung Kim, Chang Jun Coe, Dong Gwan Han, Duk Jin Yun
Clin Exp Pediatr. 1976;19(2):113-120.   Published online February 28, 1976
This is a clinical study of 32 cases with subdural effusion who has been admitted to Severance hospital from Jan. 1966 to Dec. 1975. And following result has been obtained. 1. Among 32 cases, 19 were male and 13 were female. Their ages were ranged from 3 days to 37 months with peak incidence 2 to 6 months. And 12 cases...
Perinatal Mortality Rate: I. Relationship to Maternal Obstetric Conditions
Dong Gwan Han, Kyung Sook Park
Clin Exp Pediatr. 1975;18(3):189-203.   Published online March 31, 1975
The purpose of this clinical study is to estimate the perinatal mortality rate in different hospital births which is associated with maternal obstetric conditions from Jan. 1970 through Dec. 1972. For 3 years there were 11, 880 births that were based on 11, 336 single births, 312 twin births and 232 Korean-Caucasian births who were delivered at Severance(7, 844 births),...
Perinatal Mortality Rate(I. Relationship to Birth Weight and Gestational Age)
Dong Gwan Han, Chang Jun Coe, Kyung Sook Park
Clin Exp Pediatr. 1975;18(11):789-800.   Published online November 30, 1975
We have been observed perinatal and neonatal mortality rates according to the birth weight and. gestational age of 11, 336 Korean single births born at Severance Hospital, Yonsei University, Jeon-Ju Presbyterian Hospital and Won-Ju Christian Hospital for 3 years from Jan. 1970 through Dec. 1972. 1)We have been observed 544 perinatal deaths (fetal deaths: 286 cases, neonatal deaths: 258 cases);...
Change of Laboratory Data of Blood Specimen by Stored Time
Ton Sang Park, Ghun Shik Dim, Dong Gwan Han, Duk Jin Yun
Clin Exp Pediatr. 1973;16(12):929-934.   Published online December 31, 1973
32 adult blood specimen were stored in the refrigerator which maintained the temperature from 6 to 9 degrees in centigrade in order to know the change of laboratory data by time. Routine C.B.C. and blood chemistry were performed 4 times, with the intervals, immediately after then, 6,12 and 24 hours after sampling. The results obtained are as follows: 1. Hb, Het,...
Studies on the Blood Sugar Levels with Time in Neonates
Dong Gwan Han
Clin Exp Pediatr. 1970;13(7):411-418.   Published online July 31, 1970
Although there is still disagreement for levels of blood sugar in the neonates of Caucasian race, they have measured true sugar or glucose in blood of newborm infants since 1911." Most authors agree that the blood sugar levels in full-term infants tend to decrease during the first few hours of life and only reach levek that would be in the...
Clinical Studies of Typhoid Fever in Children
Dong Gwan Han, Tae U Paik, Dong Sik Chin
Clin Exp Pediatr. 1969;12(3):149-158.   Published online March 31, 1969
During the last 10 years which was from January 1957 to December 1966, 73 cases of typhoid fever was admitted to the Department of Pediatrics, Severance Hospital and evaluated clinically. The results were obtained as follows; 1) Male was more prominent than female children and the ratio, M:F was 43:30. The peak age group was from 6 to 10 years(47.9%) and the youngest case was...
Clinical Observations of Pleurisy with Effusion and Effects of Prednisolone in Therapy
Dong Gwan Han, Se Joo Kang, Ki Joon Kim, Kyung Ja Cho, Duk Jin Yun
Clin Exp Pediatr. 1967;10(8):417-422.   Published online August 31, 1967
We observed 34 cases who were admitted to Severance Hospital in order to evaluate the efficacy of prednisolone for the treatment of pleurisy wth effusion during the period of 9 years from May, 1956 to April, 1965. Effusion occurred most commonly in the spring, least often in the autumn. Boys were affected somewhat more frequently than girls. Most of the...
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